This expanded heart health test measures key indicators of cardiovascular and metabolic health to help you and your healthcare provider understand your risk of cardiovascular disease (CVD) and developing Type 2 diabetes. Key indicators measured include apolipoprotein B (ApoB), Diabetes Risk Index (DRI), GlycA, cholesterol and lipids.
Note: This test is not intended to diagnose CVD, type 2 diabetes, or other diseases.
Preparation: Fast for 12-14 hours (no food or drink, except water) before sample collection.
By understanding your levels for key heart health indicators, you can take proactive steps to manage your health for a longer, healthier life. This heart health test can help you and your healthcare provider detect early signs of cardiometabolic conditions such as abnormal lipid levels, insulin resistance and systemic inflammation, empowering you to address these risks with lifestyle changes and preventive treatments.
If you have a family history of cardiovascular conditions or diabetes, or if you have had a previous cardiovascular event, you may be at higher risk of cardiovascular disease or Type 2 diabetes. This heart test can detect early indicators of disease and help in proactively managing potential risks.
Lifestyle changes such as healthy dietary choices, exercise or weight loss programs can help reduce risk of cardiovascular disease, Type 2 diabetes and other conditions. Testing and monitoring key heart health indicators such as ApoB, GlycA, DRI, cholesterol and lipids can help you and your healthcare provider evaluate and manage the risks associated with heart disease, diabetes and related conditions. It can also help you tailor dietary and lifestyle changes to decrease your risk.
1. Devaraj S, Semaan JR, Jialal I. Biochemistry, Apolipoprotein B. In: StatPearls. Treasure Island (FL): StatPearls Publishing; May 14, 2023.
2. Ballout RA, Remaley AT. GlycA: A new biomarker for systemic inflammation and cardiovascular disease (CVD) risk assessment. J Lab Precis Med. 2020;5:17. doi:10.21037/jlpm.2020.03.03
3. Flores-Guerrero JL, Gruppen EG, Connelly MA, et al. A Newly Developed Diabetes Risk Index, Based on Lipoprotein Subfractions and Branched Chain Amino Acids, is Associated with Incident Type 2 Diabetes Mellitus in the PREVEND Cohort. J Clin Med. 2020;9(9):2781. Published 2020 Aug 27. doi:10.3390/jcm9092781
<p><b>1. </b>Devaraj S, Semaan JR, Jialal I. Biochemistry, Apolipoprotein B. In: <i>StatPearls</i>. Treasure Island (FL): StatPearls Publishing; May 14, 2023.</p> <p><b>2. </b>Ballout RA, Remaley AT. GlycA: A new biomarker for systemic inflammation and cardiovascular disease (CVD) risk assessment. <i>J Lab Precis Med.</i> 2020;5:17. doi:10.21037/jlpm.2020.03.03</p> <p><b>3. </b>Flores-Guerrero JL, Gruppen EG, Connelly MA, et al. A Newly Developed Diabetes Risk Index, Based on Lipoprotein Subfractions and Branched Chain Amino Acids, is Associated with Incident Type 2 Diabetes Mellitus in the PREVEND Cohort. <i>J Clin Med</i>. 2020;9(9):2781. Published 2020 Aug 27. doi:10.3390/jcm9092781</p>
A measure of the total sum of cholesterol (LDL, HDL, and VLDL) circulating in the body.
Measures the amount of LDL cholesterol in the blood. LDL cholesterol is known as the “bad” cholesterol because LDL particles can build up in the walls of your arteries, which increases the risk of heart attack and stroke.
Measures the amount of HDL cholesterol in the blood. HDL is known as "good" cholesterol because it comes from particles that remove "bad "cholesterol from the body, which reduces the risk of heart disease and stroke.
Measures the amount of triglycerides, a type of fat that circulates in your blood and comes from adipose, the primary fat stored from food used to provide your energy. High triglyceride levels can increase the risk of heart disease.
Measures total cholesterol in your blood minus HDL cholesterol, representing all “bad” cholesterol types that can contribute to heart disease.
ApoB is the major protein on LDL particles which carry substances in your blood that help make plaque, a waxy fat that can block your arteries. An ApoB test measures the amount of ApoB in the blood. An elevated level of ApoB may indicate an increased risk for cardiovascular disease.1
GlycA is a biomarker for systemic inflammation and cardiometabolic risk that measures levels of glycosylated acute-phase proteins. Elevated levels of GlycA have been associated with a higher risk of various conditions, including cardiovascular disease and diabetes.2 GlycA can be a predictor of chronic inflammation, which is known to contribute to the development of these diseases.2
DRI is a biomarker score for insulin resistance and evaluates factors that contribute to your risk of developing Type 2 diabetes. This insulin resistance test goes beyond measuring blood sugar. It analyzes specific lipids (lipoproteins) and certain amino acids that are linked to insulin resistance. By combining these results, this test creates a score that healthcare providers can use to assess your risk of developing Type 2 diabetes. This is especially helpful for people with normal blood sugar levels, as it can identify those who might be at higher risk despite not yet showing classic symptoms. A higher DRI score can indicate a higher risk of developing Type 2 diabetes.3
View your easy-to-read results online in your Labcorp Patient™ account, including Linked Accounts. For certain results that require prompt attention, you will also be contacted by phone or mail.
The results of these tests are determined using state-of-the-art nuclear magnetic resonance (NMR) technology. NMR is used in the clinical laboratory for a more advanced risk assessment to help identify abnormalities that may indicate and help prevent cardiometabolic disease.
Factors such as health conditions, lifestyle, age and family history can increase your risk for heart disease. Risk factors include:
This expanded heart health test may be right for you if:
Your test results will tell you the levels of these key indicators in your blood. By understanding these levels, you and your healthcare provider can determine your risk of CVD and Type 2 diabetes and identify next steps to manage and optimize your heart health.
GlycA and high-sensitivity C-reactive protein (hs-CRP) are both blood tests used to assess inflammation, but there are key differences. GlycA measures glycosylated acute-phase proteins, offering a broad view of systemic inflammation, and it is useful in evaluating chronic conditions like cardiovascular disease and diabetes.2 In contrast, hs-CRP measures the specific level of C-reactive protein, a marker that rises quickly in response to acute inflammation, making it ideal for detecting short-term inflammatory responses and assessing cardiovascular risk.
These resources can help you learn more:
Your testing will be performed in a CLIA-certified clinical laboratory. Labcorp provides leading-edge medical laboratory tests and services through a national network of primary clinical laboratories and specialty testing laboratories. Our labs perform regular quality assurance testing to ensure our results are accurate.
Your results will be provided to you through our secure online portal to view or print. Results are also provided to PWNHealth, which provides professional healthcare provider services for OnDemand tests. If you are accessing your results through your Labcorp Patient account, all users linked to the account will have access to all OnDemand test results. Results may also be provided to a local, state, or federal health authority, but only when legally required. For example, many states require the testing laboratory and healthcare provider to report test results for certain communicable diseases, such as sexually transmitted diseases or COVID-19, to local or state health departments.
If you have questions or comments regarding the Labcorp Notice of Privacy Practices, or have a complaint about our use or disclosure of your PHI or our privacy practices, please contact: privacyofficer@labcorp.com, call us at (877) 234-4722 (877-23-HIPAA) and ask for the Labcorp HIPAA Privacy Officer, or send a written request to: HIPAA Privacy Officer, Labcorp, 531 South Spring Street, Burlington, NC 27215. You also may file a complaint with the Secretary of the U.S. Department of Health and Human Services.
Visit the Labcorp OnDemand website to browse and purchase laboratory tests and create your Labcorp OnDemand account. All Labcorp OnDemand testing requires a healthcare provider order; for your convenience, Labcorp OnDemand has contracted with PWNHealth LLC and its affiliated professional entities (collectively, PWNHealth) to provide healthcare provider services. Visit a Labcorp location for sample collection; or, if using an at-home kit, collect your sample yourself. We’ll let you know when your results are ready to be accessed through your Labcorp OnDemand account or through your Labcorp Patient account.
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