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Estradiol (E2) Test

$79

Empower yourself with answers about your estrogen level.

As the hormone responsible for developing and regulating the female reproductive system, estradiol (E2) plays an important role in the menstrual cycle, supporting pregnancy and maintaining reproductive health.

Low estradiol levels can impact your bones, brain, cardiovascular and reproductive health. If you are experiencing symptoms of dry skin, trouble concentrating, hot flashes, mood swings and menstrual changes, you may have low levels of estradiol.

The Labcorp OnDemand Estradiol (E2) Test measures the levels of estradiol in your blood to provide insights into your hormone health.

Note: This test does not diagnose or determine the cause of infertility. It is recommended to consult with a healthcare provider if you have any questions about your result.

Estradiol (E2) Test

$79

Test Details

Sample Type: Blood

Collection Method: In person at a Labcorp location

Age: 18+

Results: 1 day from when your sample arrives at our lab

HSA/FSA: Accepted

Test must be taken by purchaser

Preparation: If you are still menstruating, it is recommended to test on day 3 of your menstrual cycle (cycle day 1 is the first day of your period). If you have no menstrual cycle or have irregular menstrual cycles, you can test at any time.

If you’re taking a supplement containing biotin (also called vitamin B7 or B8, vitamin H or coenzyme R), commonly found in products promoting nail, skin and hair health, we recommend that you wait at least 72 hours from your last dose before taking the test.

What's Tested

Estradiol (E2)

Produced by the ovaries, estradiol is the most common type of estrogen. It regulates menstrual cycles in women and helps thicken the lining of the uterus. Estradiol levels fluctuate throughout the menstrual cycle, peak right before ovulation, and drop after ovulation occurs.

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Reproductive health insights

Our estradiol test is a quick and convenient way to gain information about your reproductive health to better understand your menstrual cycle, which you can then discuss with your healthcare provider.

Experiencing symptoms of a hormonal imbalance?

An estrogen hormone imbalance can cause symptoms such as irregular menstrual cycles, weight fluctuations, fatigue, and mood changes. Estrogen and progesterone work together to support the menstrual cycle, and hormonal imbalances can occur due to several factors, including the transition of menopause, stress, illness, an unbalanced diet, a sedentary lifestyle, smoking, or excessive caffeine or alcohol consumption.

It's important to remember that hormones fluctuate throughout life and menopause is a natural phase of life.

These symptoms could also be caused by other conditions. It is recommended to consult with a healthcare provider if you have any questions about your results or symptoms.

Wondering about bone health?

Estradiol plays a key role in bone health. As we age, our bodies produce less estradiol, which can lead to weaker bones.¹

1. Cleveland Clinic. Estrogen. February 8, 2022. Accessed November 14, 2023. https://my.clevelandclinic.org/health/body/22353-estrogen

2. Lindsay TJ, Vitrikas KR. Evaluation and treatment of infertility. Am Fam Physician. 2015 Mar 1;91(5):308-14. Erratum in: Am Fam Physician. 2015 Sep 15;92 (6):437.

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Purchase Your Test

Simply purchase this test online. A healthcare provider will review and approve your test requests; no healthcare provider visit is required.

Provide Your Sample

Visit a Labcorp location near you for sample collection. Visits may be scheduled online.

Get Your Results

View your easy-to-read results online in your Labcorp Patient™ account, including Linked Accounts. For certain results that require prompt attention, you will also be contacted by phone or mail.

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FAQ

The Labcorp OnDemand Estradiol Test measures the level of estradiol, a type of estrogen also known as E2, in your blood.

As estradiol plays a major role on the reproductive system, this E2 test will assess your estradiol hormone level and provide further insights into reproductive health and any signs of a hormonal imbalance. This test can provide baseline insight into menstrual cycle issues or hormonal symptoms (such as irregular periods, decreased sex drive or weight fluctuation) that you may be experiencing.

Estradiol level will vary based on several factors including your age and if you are taking certain medications (such as birth control).

Note: This E2 test does not diagnose or determine the cause of infertility. Estradiol is typically evaluated in the context of other hormone levels such as follicle-stimulating hormone. It is recommended to consult with a healthcare provider if you have any questions about your result.

This test is not intended for individuals on hormone therapy or hormonal contraception, as these may interfere with the test results. Hormone levels may fluctuate widely throughout the menstrual cycle, especially during pregnancy and the menopause transition.
For those assigned female at birth: We recommend that you test on day three of your menstrual cycle (cycle day one is the first day of your period). Since estradiol levels fluctuate throughout the menstrual cycle, results will vary on any given day. Day 3 of your menstrual cycle is considered the “baseline” because that's typically when estradiol levels are most stable.

If you have irregular menstrual cycles, you can test at any time.
Adults assigned female at birth may experience symptoms of hormonal imbalances or fluctuations during menopausal transition such as:

Fatigue
Difficulty sleeping
Loss of interest in sex
Irregular or no menstrual periods
Heavy menstrual periods
Hot flashes
Weight gain
Mood changes

If you’re experiencing new, persistent symptoms or have concerns about your estradiol levels, it’s best to consult with a healthcare provider who can interpret the results in the context of your overall health and medical history.
Hormone changes in the body trigger each of the four phases of the menstrual cycle: menstruation, follicular phase, ovulation and luteal phase.

Menstruation is the first phase of the menstrual cycle and is the shedding of lining of the uterus. During menstruation, the levels of the hormones estrogen and progesterone drop, which causes the endometrium to detach from the walls of the uterus and bleed.

Proliferative (follicular) phase is the phase of the menstrual cycle that starts after menstruation and ends with ovulation. During this phase, the ovaries produce follicles which develop into a mature egg. The level of estrogen increases, and this helps to thicken the lining of the uterus so that it can support a pregnancy. The follicles grow and mature under the influence of follicle-stimulating hormone (FSH).

Ovulation phase is when an egg is released from a follicle in the ovary. Ovulation is triggered by a surge in the hormone luteinizing hormone (LH). The egg travels down the fallopian tube towards the uterus, where it can be fertilized by a sperm.

Luteal phase begins after ovulation where the follicle that released the egg becomes a corpus luteum, which produces progesterone. Progesterone helps to maintain the thick lining of the uterus to prepare for a fertilized egg. If fertilization does not occur, the corpus luteum breaks down and the level of progesterone decreases. This causes the lining of the uterus to shed, and the menstrual cycle begins again.
Want to learn more about estradiol testing, hormonal imbalance or key hormones in women? Here are some additional resources to help you stay informed about your hormone health:

Labcorp OnDemand: Guide on Hormone Health for Women
Cleveland Clinic: Hormone Imbalance
National Institutes of Health – Medline Plus: Estradiol Blood Test
The American College of Obstetricians and Gynecologists: The Menstrual Cycle (Infographic)
Your results will be provided to you through our secure online portal to view or print. Results are also made available through a secure portal to the independent healthcare provider who placed your test order. If you are accessing your results through your Labcorp Patient™ account, all users linked to the account will have access to all OnDemand test results. Results may also be provided to a local, state, and/or federal health authority; for example, many states require the testing laboratory and physician to report test results for certain communicable diseases, such as COVID-19, to local or state health departments.

If you have questions or comments regarding the Labcorp Notice of Privacy Practices, or have a complaint about our use or disclosure of your PHI or our privacy practices, please contact: privacyofficer@labcorp.com, call us at (877) 234-4722 (877-23-HIPAA) and ask for the Labcorp HIPAA Privacy Officer, or send a written request to: HIPAA Privacy Officer, Labcorp, 531 South Spring Street, Burlington, NC 27215. You also may file a complaint with the Secretary of the U.S. Department of Health and Human Services.
Visit the Labcorp OnDemand® website to browse and purchase laboratory tests and create your Labcorp Patient™ account to view your results. All Labcorp OnDemand testing requires an order from an authorized healthcare professional. For your convenience, Labcorp OnDemand has contracted with independent professional entities (collectively, Providers) to deliver healthcare provider services. Visit a Labcorp location for sample collection; or, if using an at-home collection kit, collect your sample yourself. We’ll let you know when your results are ready and can be accessed through your Labcorp Patient™ account.

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Estradiol (E2) Test

Empower yourself with answers about your estrogen level.

Test Details